Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes
Identifieur interne : 004115 ( Main/Exploration ); précédent : 004114; suivant : 004116Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes
Auteurs : Sophia Zoungas [Australie] ; Mark Woodward [Australie, États-Unis] ; QIANG LI [Australie] ; Mark E. Cooper [Australie] ; Pavel Hamet [Canada] ; Stephen Harrap [Australie] ; Simon Heller [Royaume-Uni] ; Michel Marre [France] ; Anushka Patel [Australie] ; Neil Poulter [Royaume-Uni] ; Bryan Williams [Royaume-Uni] ; John Chalmers [Australie]Source :
- Diabetologia : (Berlin) [ 0012-186X ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Mortalité.
English descriptors
- KwdEn :
Abstract
Aims/hypothesis Data are inconsistent regarding the associations between age, age at diagnosis of diabetes, diabetes duration and subsequent vascular complications. Methods The associations between age (or age at diagnosis), diabetes duration and major macrovascular events, all-cause death and major microvascular events were examined in 11,140 patients with type 2 diabetes randomly allocated to intensive or standard glucose control in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Rates were calculated by 5 year baseline age (or age at diagnosis) and diabetes duration strata. Risks were estimated using Cox models adjusted for treatment assignment and HbA1c. Results The mean age (±SD) was 65.8±6.4 years, age at diagnosis was 57.8±8.7 years and diabetes duration was 7.9±6.4 years. Diabetes duration was associated with the risk of macrovascular events (HR 1.13 [95% CI 1.08, 1.17]), microvascular events (1.28 [1.23, 1.33]) and death (1.15 [1.10, 1.20]) whereas age (or age at diagnosis) was only associated with the risk of macrovascular events (1.33 [1.27, 1.39]) and death (1.56 [1.48, 1.64]). No interaction was observed between diabetes duration, age and the risk of macrovascular events or death (both p>0.4). However, an interaction was observed between diabetes duration, age and the risk of microvascular events (p=0.002), such that the effects of increasing diabetes duration were greatest at younger rather than older age. Conclusions/interpretation In patients with type 2 diabetes, age or age at diagnosis and diabetes duration are independently associated with macrovascular events and death whereas only diabetes duration is independently associated with microvascular events and this effect is greater in the youngest patients.
Affiliations:
- Australie, Canada, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Nouvelle-Galles du Sud, Victoria (État), Île-de-France
- Londres, Melbourne, Paris, Sydney
- Université de Melbourne, Université de Sydney
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes</title><author><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Public Health and Preventive Medicine, Monash University</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, VIC</wicri:noRegion></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Johns Hopkins University</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Qiang Li" sort="Qiang Li" uniqKey="Qiang Li" last="Qiang Li">QIANG LI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Cooper, Mark E" sort="Cooper, Mark E" uniqKey="Cooper M" first="Mark E." last="Cooper">Mark E. Cooper</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Baker IDI Heart and Diabetes Institute</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart and Diabetes Institute</wicri:noRegion></affiliation></author><author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Research Centre, Centre hospitalier de l'Université de Montréal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC</wicri:noRegion></affiliation></author><author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>The Royal Melbourne Hospital, University of Melbourne</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Heller, Simon" sort="Heller, Simon" uniqKey="Heller S" first="Simon" last="Heller">Simon Heller</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>University ot Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</s1><s2>Sheffield</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University ot Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hôpital Bichat-Claude Bernard and Université Paris 7</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institute of Cardiovascular Science, University College</s1><s2>London</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand 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Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Public Health and Preventive Medicine, Monash University</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, VIC</wicri:noRegion></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Johns Hopkins University</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Qiang Li" sort="Qiang Li" uniqKey="Qiang Li" last="Qiang Li">QIANG LI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Cooper, Mark E" sort="Cooper, Mark E" uniqKey="Cooper M" first="Mark E." last="Cooper">Mark E. Cooper</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Baker IDI Heart and Diabetes Institute</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart and Diabetes Institute</wicri:noRegion></affiliation></author><author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Research Centre, Centre hospitalier de l'Université de Montréal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC</wicri:noRegion></affiliation></author><author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>The Royal Melbourne Hospital, University of Melbourne</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Heller, Simon" sort="Heller, Simon" uniqKey="Heller S" first="Simon" last="Heller">Simon Heller</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>University ot Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</s1><s2>Sheffield</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University ot Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hôpital Bichat-Claude Bernard and Université Paris 7</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institute of Cardiovascular Science, University College</s1><s2>London</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for Global Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Camperdown, Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Diabetologia : (Berlin)</title><title level="j" type="abbreviated">Diabetologia : (Berl.)</title><idno type="ISSN">0012-186X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Diabetologia : (Berlin)</title><title level="j" type="abbreviated">Diabetologia : (Berl.)</title><idno type="ISSN">0012-186X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term><term>Diagnosis</term><term>Duration</term><term>Microangiopathy</term><term>Mortality</term><term>Occlusive arterial disease</term><term>Risk factor</term><term>Type 2 diabetes</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Age</term><term>Diagnostic</term><term>Durée</term><term>Facteur risque</term><term>Microangiopathie</term><term>Mortalité</term><term>Diabète de type 2</term><term>Artériopathie oblitérante</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aims/hypothesis Data are inconsistent regarding the associations between age, age at diagnosis of diabetes, diabetes duration and subsequent vascular complications. Methods The associations between age (or age at diagnosis), diabetes duration and major macrovascular events, all-cause death and major microvascular events were examined in 11,140 patients with type 2 diabetes randomly allocated to intensive or standard glucose control in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Rates were calculated by 5 year baseline age (or age at diagnosis) and diabetes duration strata. Risks were estimated using Cox models adjusted for treatment assignment and HbA<sub>1c</sub>. Results The mean age (±SD) was 65.8±6.4 years, age at diagnosis was 57.8±8.7 years and diabetes duration was 7.9±6.4 years. Diabetes duration was associated with the risk of macrovascular events (HR 1.13 [95% CI 1.08, 1.17]), microvascular events (1.28 [1.23, 1.33]) and death (1.15 [1.10, 1.20]) whereas age (or age at diagnosis) was only associated with the risk of macrovascular events (1.33 [1.27, 1.39]) and death (1.56 [1.48, 1.64]). No interaction was observed between diabetes duration, age and the risk of macrovascular events or death (both p>0.4). However, an interaction was observed between diabetes duration, age and the risk of microvascular events (p=0.002), such that the effects of increasing diabetes duration were greatest at younger rather than older age. Conclusions/interpretation In patients with type 2 diabetes, age or age at diagnosis and diabetes duration are independently associated with macrovascular events and death whereas only diabetes duration is independently associated with microvascular events and this effect is greater in the youngest patients.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Melbourne</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name></region><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Cooper, Mark E" sort="Cooper, Mark E" uniqKey="Cooper M" first="Mark E." last="Cooper">Mark E. Cooper</name><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name><name sortKey="Qiang Li" sort="Qiang Li" uniqKey="Qiang Li" last="Qiang Li">QIANG LI</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name></country><country name="États-Unis"><noRegion><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Heller, Simon" sort="Heller, Simon" uniqKey="Heller S" first="Simon" last="Heller">Simon Heller</name></noRegion><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name></country><country name="France"><region name="Île-de-France"><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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